-Rh prophylaxis in obstetric complications or invasive procedures RhoGAM may be administered if MICRhoGAM is not available. Obstetric complications/invasive procedures: Uses: Rhophylac(R): 1500 international units (300 mcg), IV or IM, within 72 hours of complication, plus: 6-8 After the 12th week of gestation, a standard dose of HyperRHO S/D Full Dose is indicated. Dose and route varies for each product. RhoGAM (rho(d) immune globulin … Ectopic pregnancy: -IVH can lead to clinically compromising anemia and multi-system organ failure including acute respiratory distress syndrome (ARDS). -100 international units (20 mcg) per mL fetal red blood cells in excess of 15 mL if transplacental bleeding is quantified Start studying RhoGAM. -Transfusion of less than 2.5 mL of incompatible blood: 250 international units (50 mcg), IM, within 72 hours of exposure HyperRHO S/D Mini-Dose(R): 1 syringe, IM, within 3 hours, or as soon as possible (within 72 hours of pregnancy termination). ITP is a type of blood disorder where the person has a very low number of platelets. The product's dosage form is injection, solution, and is administered via intramuscular form. A 50- or 120-mcg dose is recommended before 12 weeks' gestation, although 300 mcg can be administered if lower doses are not available.3 After 12 weeks, a 300-mcg dose should be given.12. Incompatible transfusions: Administer within 72 hours of suspected or proven exposure to Rh-positive red blood cells. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. WinRho(R): 1500 international units (300 mcg), IV or IM, at gestational week 28; give an additional 600 international units (120 mcg) dose within 72 hours of birth of an RHo (D) positive baby. Actual or threatened termination of pregnancy (spontaneous or induced) up to and including 12 weeks gestation. Some people are allergic to this medication and should not use it. This may be determined by use of qualitative or quantitative tests for fetal-maternal hemorrhage. -Transfusion of 2.5 to 15 mL incompatible blood: 1500 international units (300 mcg), IM, within 72 hours of exposure. MICRhoGAM(R) or RhoGAM(R): The J code has a dosage of 300 mcq (1500 i.u.) This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. HyperRHO S/D Full Dose is a sterilized solution made from human blood. Hgb 8 to 10 g/dL: 125 to 200 international units/kg (25 to 40 mcg/kg) MICRhoGAM is indicated within 72 hours after termination of pregnancy up to and including 12 weeks gestation. -Serious complications, including severe anemia, acute renal insufficiency, renal failure, and disseminated intravascular coagulation (DIC) have been reported. Brand Names: BayRHo-D, BayRHo-D Full Dose, BayRHo-D Mini-Dose, HyperRHO S/D Full Dose, HyperRHO S/D Mini Dose, MicRhoGAM, MicRhoGAM Ultra-Filtered Plus, RhoGAM, RhoGAM Ultra-Filtered Plus, Rhophylac, WinRho SDF Generic Name: RHo (D) immune globulin. However, in clinical practice, laboratory methods used to determine the amount of exposure (volume of transfusion or FMH) to Rh-positive red blood cells are imprecise. OR Rh is a substance that most people have in their blood (Rh positive) but some people don't (Rh negative). This is the dose for the indications associated with pregnancy at or beyond 13 weeks unless there is clinical or laboratory evidence of a fetal-maternal hemorrhage (FMH) in excess of 15 mL of Rh-positive red blood cells. Administer injection per standard protocol. Rhophylac(R): Increase the dose based on guidelines for excessive fetomaternal hemorrhage. RhoGAM®Ultra-Filtered PLUS [Rho(D) Immune Globulin (Human)] (300 μg), is a prescription medicine given by intramuscular injection that is used to prevent Rh immunization, a condition in which an individual with Rh-negative blood develops antibodies after exposure to Rh-positive blood. -Initial dose if hemoglobin (Hgb) less than 10 g/dL: Dispose of the syringe in accordance with local regulations. The total dosage must be injected within 72 hours postpartum or after the transfusion accident. Therefore, administration of more than 20 µg of RhoGAM per mL of Rh-positive red blood cells should be considered whenever a large FMH or red blood cell exposure is suspected or documented. Individual course: $20: Add to cart: The page below is a sample from the LabCE course Hemolytic Disease of the Fetus and Newborn (retired 4/6/2020). -Absence of these signs or symptoms within 8 hours do not indicate that IVH cannot occur subsequently. 2 Official descriptor for J2790-Injection, Rho(D) Immune globulin, human full dose, 300 mcg 3 Official descriptor for J2788-Injection, Rho(D) Immune globulin, human, minidose, 50 mcg 4 International Classification of Diseases, Ninth Revision, Clinical Modifications (ICD-9-CM) Thank you. If delivery occurs within three weeks after the last antepartum dose, the postpartum dose may be withheld, but a test for fetal-maternal hemorrhage should be performed to determine if exposure to > 15 mL of red blood cells has occurred. -Never administer HyperRHO S/D Mini-Dose(R) or BayRho-D Mini-Dose(R) intravenously. Hyper RHO S/D Mini-Dose (R) should not be injected into the gluteal region because of the risk of injury to the sciatic nerve. 2.5 - 15.0 mL Rh-positive red blood cells. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. -Intravascular hemolysis (IVH) leading to death has been reported in patients on this drug for immune thrombocytopenic purpura (ITP). Excessive fetomaternal hemorrhage: -Incompatible transfusions in Rho (D)-negative individuals (given Rho (D)-positive blood cells), Rhophylac(R): 250 international units (50 mcg) per kg, IV, at 2 mL per 15 to 60 seconds RhoGAM and MicRhoGAM are clear or slightly opalescent. If antepartum prophylaxis is indicated, it is essential that the mother receive a postpartum dose if the infant is Rh-positive. Rhogam; RhoGAM Ultra-Filtered Plus; Rhophylac; Canadian Brand Name. 90 international units (18 mcg) per mL red blood cells After injection, to engage the safety guard, use free hand to slide safety guard over needle. prednisone, triamcinolone, dexamethasone, Decadron, Promacta, RhoGAM, Nplate, rho (d) immune globulin, RhoGAM Ultra-Filtered Plus. Monitoring: Select one or more newsletters to continue. Immune Thrombocytopenic Purpura (Nonsplenectomized Rho (D)-Positive Patients) Initial, Hgb >10 g/dL: 250 IU/kg IV once. -Routine antepartum and postpartum Rh prophylaxis -If the Rh status of the baby is not known at 72 hours, administer WinRho(R). -Alert patients and monitor for signs and symptoms of IVH including back pain, shaking chills, fever, and discolored urine or hemoglobinuria. The criteria for the administration of Rho (D) immune globulin for a Rh incompatible pregnancy are: WinRho(R): Use: Immune thrombocytopenic purpura (ITP): The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A single dose lasts 12 weeks. Request a Demo 14 Day Free Trial Buy Now. Administration advice: Winrho SDF; Winrho SDF; Descriptions. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. -Closely monitor patients for ITP in a healthcare setting for at least 8 hours after administration. -Patient did not respond to initial dose of WinRho(R), dosing based on hemoglobin: Hgb under 8 g/dL: Use alternative treatment Threatened abortion at any time: Patients known or suspected to be at increased risk of FMH should be tested for FMH by qualitative or quantitative methods.3 In efficacy studies, RhoGAM was shown to suppress Rh immunization in all subjects when given at a dose of > 20 µg per mL of Rh-positive red blood cells. Rho immune globulin is a medication used to prevent RhD isoimmunization in mothers who are RhD negative and to treat idiopathic thrombocytopenic purpura in people who are Rh positive. -Raising platelet counts in Rho (D)-positive, non-splenectomized chronic ITP, Dose and route varies for each product. We comply with the HONcode standard for trustworthy health information -, Postpartum (if the newborn is Rh-positive). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The amount of anti-Rh o (D) in HyperRHO S/D Mini-Dose has been shown to effectively prevent maternal isosensitization to the Rh o (D) antigens following spontaneous or induced abortion occurring up to the 12th week of gestation. Amniocentesis, chorionic villus sampling (CVS) and percutaneous umbilical blood sampling (PUBS), Abdominal trauma or obstetrical manipulation, Threatened pregnancy loss after 12 weeks gestation with continuation of pregnancy, Pregnancy termination (spontaneous or induced) beyond 12 weeks gestation. The PDR cautions that the use of rhogam during pregnancy can have adverse effects on the fetus, 2. This dose will suppress the immune response to up to 2.5 mL of Rh-positive red blood cells. If subsequent therapy is needed to elevate platelet counts: RhoGAM(R): 1500 international units (300 mcg), IM Each single dose prefilled syringe of RhoGAM contains 300 mcg (1500 IU) of Rho(D) Immune Globulin (Human) This is the dose for the indications associated with pregnancy at or beyond 13 weeks unless there is clinical or laboratory evidence of a fetal-maternal hemorrhage (FMH) in excess of 15 mL of Rh-positive red blood cells 45 international units (9 mcg) per mL whole blood In most cases you will receive a dose of RhoGAM between 26-28 weeks of pregnancy If your baby is found to be Rh-positive at birth, you will receive a second dose within 72 hours after delivery* Multiple doses may be administered at the same time or at spaced intervals, as long as the total dose is administered within three days of exposure.1, Transfusion of Rh-incompatible blood or blood products. Several Rho (D) immune globulin products are not for IV use. Intramuscular dosage (HyperRHO S/D Full dose and RhoGAM only) Adults 300 mcg (1500 international units) IM should be given for every 15 ml of … If delivery of the baby does not occur 12 weeks after the administration of the standard antepartum dose (at 26 to 28 weeks), a second dose is recommended to maximize protection antepartum. Other brands: RhoGAM, RhoGAM Ultra-Filtered Plus, Rhophylac, HyperRHO S/D Full Dose, ... +5 more. In some cases, the mother must receive the Rho(D) immune globulin. -Maintenance dose: 125 to 300 international units/kg (25 to 60 mcg/kg), IV, over 3 to 5 minutes Maltose in IVIG products, such as the liquid formulation of WinRho SDF, has been shown to give false high blood glucose levels in certain types of blood glucose testing systems. Additional doses of RhoGAM are indicated when the patient has been exposed to > 15 mL of Rh-positive red blood cells. -Administer 3,000 international units (600 mcg) IV every 8 hours until the total dose (calculated from the above doses) is administered. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 3. Rhophylac(R): 1500 international units (300 mcg), IV or IM, at gestational week 29 to 30; repeat dose within 72 hours of birth of an RHo (D) positive baby. Abortion or miscarriage of up to 12 weeks gestation: WinRho(R): 125 to 300 international units/kg (25 to 60 mcg/kg), IV, over 3 to 5 minutes MICRhoGAM(R) or RhoGAM(R): 250 international units (50 mcg), IM, within 72 hours of actual or threatened pregnancy termination. Medically reviewed by Drugs.com. Suppression of Rh isoimmunization in: Initial, Hgb <10 g/dL: 125-200 IU/kg IV once. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. RHo (D) immune globulin is a sterilized solution made from human blood. Additional doses of RhoGAM are indicated when the patient has been exposed to > 15 mL of Rh-positive red blood cells. Rho (D) immune globulin should not be administered to the infant for the suppression of Rh isoimmunization in the mother. US BOXED WARNING(S): INTRAVASCULAR HEMOLYSIS Rhogam is a type of vaccine but not a vaccine directed against an infectious disease. IV administration: RhoGAM may be administered if MICRhoGAM is not available. This is the dose for the indications associated with pregnancy at or beyond 13 weeks unless there is clinical or laboratory evidence of a fetal-maternal hemorrhage (FMH) in excess of 15 mL of Rh-positive red blood cells. Rh-incompatible pregnancy: RhoGAM(R): 1500 international units (300 mcg), IM, at gestational week 26 to 28, or within 72 hours of birth of an RHo (D) positive baby. HCPCS code J2790 for Injection, Rho D immune globulin, human, full dose, 300 micrograms (1500 IU) as maintained by CMS falls under Drugs, Administered by Injection . Find everything you need to know about Rhogam (Rho (D) Immune Globulin), including what it is used for, warnings, reviews, side effects, and interactions.

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